Natural Nighttime Gummies with Passion Flower & Melatonin

Melatonin is a hormone that your brain produces in response to darkness. It helps with the timing of your circadian rhythms (24-hour internal clock) and with sleep. Being exposed to light at night can block melatonin production.

Research suggests that melatonin plays other important roles in the body beyond sleep. However, these effects are not fully understood.

Melatonin dietary supplements can be made from animals or microorganisms, but most often they’re made synthetically. The information below is about melatonin dietary supplements. (1)

(1) Melatonin: What You Need To Know: https://www.nccih.nih.gov/health/melatonin-what-you-need-to-know

Melatonin (MLT) is crucial in controlling human sleep-wake patterns. While it has long been recognized for regulating circadian rhythms, its demonstrated efficacy in managing various diseases has recently gained considerable attention. This review discusses MLT's potential preventative and therapeutic effects on various diseases. Several studies have focused on examining the molecular mechanisms through which MLT brings about its protective or therapeutic effects on various diseases, including cancer, obesity, coronavirus, and cardiovascular diseases. Numerous preventative and therapeutic applications of MLT have been proposed, resulting from its ability to function as an antioxidant, anti-cancer, anti-inflammatory, and immune-regulating agent. There is a need for further research to determine MLT's long-term effects on antioxidant defense systems, its preventative and therapeutic benefits, and its molecular basis. (2)

(2) Melatonin Benefits: https://pubmed.ncbi.nlm.nih.gov/39312371/

Anxiety disorders are the most common mental diseases. Anxiety and the associated physical symptoms may disturb social and occupational life and increase the risk of somatic diseases. The pathophysiology of anxiety development is complex and involves alterations in stress hormone production, neurosignaling pathways or free radical production. The various manifestations of anxiety, its complex pathophysiological background and the side effects of available treatments underlie the quest for constantly seeking therapies for these conditions. Melatonin, an indolamine produced in the pineal gland and released into the blood on a nightly basis, has been demonstrated to exert anxiolytic action in animal experiments and different clinical conditions. This hormone influences a number of physiological actions either via specific melatonin receptors or by receptor-independent pleiotropic effects. The underlying pathomechanism of melatonin’s benefit in anxiety may reside in its sympatholytic action, interaction with the renin–angiotensin and glucocorticoid systems, modulation of interneuronal signaling and its extraordinary antioxidant and radical scavenging nature. Of importance, the concentration of this indolamine is significantly higher in cerebrospinal fluid than in the blood. Thus, ensuring sufficient melatonin production by reducing light pollution, which suppresses melatonin levels, may represent an endogenous neuroprotective and anxiolytic treatment. Since melatonin is freely available, economically undemanding and has limited side effects, it may be considered an additional or alternative treatment for various conditions associated with anxiety. (3) 

(3) Melatonin Anxiety: https://pmc.ncbi.nlm.nih.gov/articles/PMC9788115/

Despite the lack of FDA approval, the American Academy of Family Physicians (AAFP) recognizes melatonin as the first-line pharmacological therapy for insomnia, emphasizing its crucial role in managing sleep-related concerns. This drug is relatively safe with a low risk of adverse effects. Research on the efficacy of melatonin supplementation for treating insomnia has shown varied results. However, a meta-analysis conducted by Ferracioli-Oda et al concluded that individuals who used melatonin experienced an average reduction in sleep onset latency by approximately 7 minutes, an increase in total sleep duration by approximately 8 minutes, and subjectively reported an improvement in the quality of their sleep, as compared to those who were given a placebo. Nevertheless, there was considerable variability in doses, study outcomes, and overall study quality. (4)

(2) Melatonin - https://www.ncbi.nlm.nih.gov/books/NBK534823/

(3) Ferracioli-Oda E, Qawasmi A, Bloch MH. Meta-analysis: melatonin for the treatment of primary sleep disorders. PLoS One. 2013;8(5):e63773. [PMC free article] [PubMed]

Passionflower (Passiflora incarnata) is a climbing vine with white and purple flowers, native to the southeastern United States and Central and South America, that has been used traditionally for its calming properties.

Passionflower holds potential as a natural remedy for anxiety and sleep problems. However, more research is needed to fully understand its benefits and risks. Always discuss its use with a healthcare provider to ensure it's safe and appropriate for you. (5)

Yes, passionflower (specificallyPassiflora incarnata) may help with stress and anxiety. (6)